For patients

ORION-4 is testing a new medication called inclisiran which helps to lower bad (LDL) cholesterol.

I had a heart attack back in 2007, and my doctors only know how to treat me now, with statins and aspirin and the like, because 20 years ago people like me joined earlier studies. So I think it's my duty to take part in trials like this, and without volunteers nothing will get better.David Hughes, study participant

The study scientists want to find out whether having an injection of inclisiran every six months prevents heart attacks, strokes and other circulatory problems. This study is coordinated by the University of Oxford and co-sponsored by the University of Oxford and Novartis. Recruitment to the study is complete and 16,124 people are taking part in the trial in the UK and the US. 

We are enormously grateful to the 13,190 people who have volunteered for the trial in the UK. Research studies like ORION-4, which are needed to find out which treatments benefit patients, are only possible thanks to volunteers like you.