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An overview of the available content on this site. Keep the pointer still over an item for a few seconds to get its description.
- Privacy Notice for ORION-4 UK participants
- ORION-4 newsletter, spring 2024
- Participant meetings
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Participant meetings FAQ
- Have any bad side effects been reported?
- Can inclisiran have any effect on the liver like some statins do?
- Will my cholesterol be lowered too much, affecting my brain health?
- Can this drug be used by people with a history of stroke as well as heart disease?
- How are the effects of inclisiran measured over time?
- What is the purpose of the placebo in the trial?
- Should I take statins as well as inclisiran if prescribed the drug?
- Is the build-up of plaque in arteries reversible or can it only be halted?
- Will this drug ever be available in tablet form?
- Is the ultimate aim to replace statins with this drug?
- What happens when the study ends in 2026?
- Will participants be informed if they've received the active drug or placebo at the end of the study?
- Will I be prioritised for this treatment after the trial is over? If I've been on inclisiran during the trial, will I be able to continue the drug after the trial ends?
- Will there be a follow-up study for long-term monitoring?
- What happens if I miss a dose or need surgery close to my scheduled injection?
- How can I find out my cholesterol levels during the study?
- Why did the trial take longer than expected to recruit participants?
- What if I want to withdraw from the trial?
- Are there any drugs that should not be taken during the trial?
- How does the drug work?
- How is the study funded?
- Can my participation in this trial affect my travel insurance?
- Can the drug be self-injected?
- How is the study funded?
- Can my participation in this trial affect my travel insurance?
- Can the drug be self-injected?
- Have any bad side effects been reported?
- What is the medicine being tested and how does it work?
- How does the drug work? (diagram)
- How have we identified potential participants, and do those invited have to take part?
- Who decides what treatment participants get given?
- What does taking part in ORION-4 involve?
- What happens at appointments? (summary table)
- What if a participant doesn't want to carry on with the study?
- What happens to blood samples?
- How might stored samples contribute to future research?
- What are the benefits and risks of taking part in this study?
- What will happen at the end of the study?
- How will information be collected and processed?
- What if there is a problem?
- How can I find out more about cardiovascular disease?